Genomic and functional determinants of host spectrum in Group B Streptococcus
Issued Date
2024-08-01
Resource Type
ISSN
15537366
eISSN
15537374
Scopus ID
2-s2.0-85201045578
Journal Title
PLoS Pathogens
Volume
20
Issue
8 August
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS Pathogens Vol.20 No.8 August (2024)
Suggested Citation
Crestani C., Forde T.L., Bell J., Lycett S.J., Oliveira L.M.A., Pinto T.C.A., Cobo-Ángel C.G., Ceballos-Márquez A., Phuoc N.N., Sirimanapong W., Chen S.L., Jamrozy D., Bentley S.D., Fontaine M., Zadoks R.N. Genomic and functional determinants of host spectrum in Group B Streptococcus. PLoS Pathogens Vol.20 No.8 August (2024). doi:10.1371/journal.ppat.1012400 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100530
Title
Genomic and functional determinants of host spectrum in Group B Streptococcus
Author's Affiliation
University of Agriculture and Forestry, Hue University
Universidad de Caldas
A-Star, Genome Institute of Singapore
Department of Medicine
University of Edinburgh, Roslin Institute
The University of Sydney
Moredun Research Institute
Mahidol University
Wellcome Sanger Institute
College of Medical, Veterinary & Life Sciences
Universidade Federal do Rio de Janeiro
Universidad de Caldas
A-Star, Genome Institute of Singapore
Department of Medicine
University of Edinburgh, Roslin Institute
The University of Sydney
Moredun Research Institute
Mahidol University
Wellcome Sanger Institute
College of Medical, Veterinary & Life Sciences
Universidade Federal do Rio de Janeiro
Corresponding Author(s)
Other Contributor(s)
Abstract
Group B Streptococcus (GBS) is a major human and animal pathogen that threatens public health and food security. Spill-over and spill-back between host species is possible due to adaptation and amplification of GBS in new niches but the evolutionary and functional mechanisms underpinning those phenomena are poorly known. Based on analysis of 1,254 curated genomes from all major GBS host species and six continents, we found that the global GBS population comprises host-generalist, host-adapted and host-restricted sublineages, which are found across host groups, preferentially within one host group, or exclusively within one host group, respectively, and show distinct levels of recombination. Strikingly, the association of GBS genomes with the three major host groups (humans, cattle, fish) is driven by a single accessory gene cluster per host, regardless of sublineage or the breadth of host spectrum. Moreover, those gene clusters are shared with other streptococcal species occupying the same niche and are functionally relevant for host tropism. Our findings demonstrate (1) the heterogeneity of genome plasticity within a bacterial species of public health importance, enabling the identification of high-risk clones; (2) the contribution of inter-species gene transmission to the evolution of GBS; and (3) the importance of considering the role of animal hosts, and the accessory gene pool associated with their microbiota, in the evolution of multi-host bacterial pathogens. Collectively, these phenomena may explain the adaptation and clonal expansion of GBS in animal reservoirs and the risk of spill-over and spill-back between animals and humans.