Re- Infection Rate of Opisthorchis Viverrini Five Years After Treatment with Praziquantel in High-Risk Area: A Community-Based Study
Issued Date
2024-01-01
Resource Type
ISSN
15137368
eISSN
2476762X
Scopus ID
2-s2.0-85202784988
Journal Title
Asian Pacific Journal of Cancer Prevention
Volume
25
Issue
8
Start Page
2679
End Page
2684
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention Vol.25 No.8 (2024) , 2679-2684
Suggested Citation
Saengsawang P., Buakate P. Re- Infection Rate of Opisthorchis Viverrini Five Years After Treatment with Praziquantel in High-Risk Area: A Community-Based Study. Asian Pacific Journal of Cancer Prevention Vol.25 No.8 (2024) , 2679-2684. 2684. doi:10.31557/APJCP.2024.25.8.2679 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101095
Title
Re- Infection Rate of Opisthorchis Viverrini Five Years After Treatment with Praziquantel in High-Risk Area: A Community-Based Study
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Author's Affiliation
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Abstract
Background: Opisthorchis viverrini (OV) is a significant public health problem in Thailand, and OV reinfection poses a serious risk of cholangiocarcinoma with little evidence of a decrease. While numerous studies have explored OV reinfection and prevalence, most have been limited to short study period. Therefore, there is a need for long-term investigations to gather sufficient evidence. Objectives: This study aimed to access the current status of re-infection rates in high- risk areas and to determine associations between factors of and re-infection of OV at 5 years after treatment with praziquantel. Materials and Methods: In total, this study included 457 participants from a cohort study. Each participant was required to answer a questionnaire and undergo stool examination using the formalin ethyl acetate concentration technique. Data were analyzed using descriptive statistics and multiple logistic regression. Result: Out of the total 457 participants, 418 (91.5%) successfully completed the questionnaires and underwent stool examinations. Among the participants, 10.8% showed re-infection with OV. Using multivariate analysis, factors significantly associated with reinfection OV included yearly income (OR adj = 2.14, 95%CI = 1.11- 4.12, p-value = 0.022) and past stool examination five years (OR adj = 2.47, 95%CI = 1.13–5.43, p-value = 0.023), respectively. Conclusions: Subjects who frequently experience OV reinfection should undergo CCA screening by experts while closely monitoring their raw fish consumption behavior. Moreover, it is essential to implement comprehensive programs aimed at promoting behavioral changes and provide preventive education, with a specific focus on high epidemic areas, to discourage the consumption of raw fish.