Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea
Issued Date
2024-01-01
Resource Type
ISSN
00155632
eISSN
18749356
Scopus ID
2-s2.0-85206993574
Journal Title
Folia Microbiologica
Rights Holder(s)
SCOPUS
Bibliographic Citation
Folia Microbiologica (2024)
Suggested Citation
Ha J.H., Shin J.I., Kim K.M., Choi J.G., Trinh M.P., Anh W.J., Kang K.M., Kang H.L., Byun J.H., Boonyanugomol W., Kwon K.W., Jung M.H., Baik S.C., Lee W.K., Shin M.K. Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea. Folia Microbiologica (2024). doi:10.1007/s12223-024-01205-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101793
Title
Prevalence and virulence profiles of ESBL-producing Escherichia coli in urinary and blood infections in South Korea
Corresponding Author(s)
Other Contributor(s)
Abstract
Escherichia coli is a significant pathogen in extraintestinal infections, and ESBL-producing E. coli poses a major clinical challenge due to its antibiotic resistance. This study comprehensively analyzed E. coli isolates from urine and blood samples of patients with urinary tract and bloodstream infections at three major tertiary hospitals in South Korea. The goal was to provide insights into the distribution, antibiotic resistance, and virulence factors of these strains. Our analysis identified CTX-M and TEM as the dominant ESBL types, found in 71.7% and 61.7% of isolates, respectively, with 46.7% showing co-occurrence. Multilocus sequence typing (MLST) revealed the predominance of high-risk clones such as ST131, ST69, ST73, and ST95, with rare sequence types like ST410 and ST405 also identified. The high prevalence of virulence factors, including iutA (80.8%) and kpsMII (74.2%), further highlights the complexity of these strains. In addition, 38.3% of clinical isolates contained a combination of siderophore, adhesin, protectin, and toxin-related genes. There was no significant difference between urinary tract and bloodstream infections or regional differentiation in Korea. This study highlights the importance of controlling ESBL-producing E. coli infections, especially given the increasing incidence among patients with underlying medical conditions and older adults who are more susceptible to urinary tract infections. These findings serve as valuable indicators for pathogen analysis, especially those harboring antibiotic resistance and toxin genes. The insights gained are expected to contribute significantly to the development of infectious disease prevention and control strategies.