Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100
Issued Date
2024-01-01
Resource Type
ISSN
14786419
eISSN
14786427
Scopus ID
2-s2.0-85207285041
Pubmed ID
39428755
Journal Title
Natural Product Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research (2024)
Suggested Citation
Thamsiri P., Rukachaisirikul V., Phongpaichit S., Preedanon S., Sakayaroj J., Muanprasat C., Hadsadee S., Jungsuttiwong S. Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100. Natural Product Research (2024). doi:10.1080/14786419.2024.2416515 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101863
Title
Penicitrisochromans A-C, new isochromans from the marine-derived fungus Penicillium citrinum PSU-MF100
Corresponding Author(s)
Other Contributor(s)
Abstract
Three new isochroman derivatives, penicitrisochromans A-C (1-3), together with 25 known polyketides were isolated from the marine-derived fungus Penicillium citrinum PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of 3 were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, ω-hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant Staphylococcus aureus with MIC values of 32, 16 and 4 µg/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against Candida albicans NCPF3153 and Cryptococcus neoformans ATCC90112 with the respective MIC values of 16 and 64 µg/mL.