Novel Mastadenovirus Infection as Cause of Pneumonia in Imported Black-and-White Colobuses (Colobus guereza), Thailand
Issued Date
2024-12-01
Resource Type
ISSN
10806040
eISSN
10806059
Scopus ID
2-s2.0-85210746399
Journal Title
Emerging Infectious Diseases
Volume
30
Issue
12
Start Page
2544
End Page
2558
Rights Holder(s)
SCOPUS
Bibliographic Citation
Emerging Infectious Diseases Vol.30 No.12 (2024) , 2544-2558
Suggested Citation
Piewbang C., Wardhani S.W., Poonsin P., Lohavicharn P., Tengtawon R., Charoenrat T., Lacharoje S., Kesdangsakonwut S., Kasantikul T., Kosoltanapiwat N., Techangamsuwan S. Novel Mastadenovirus Infection as Cause of Pneumonia in Imported Black-and-White Colobuses (Colobus guereza), Thailand. Emerging Infectious Diseases Vol.30 No.12 (2024) , 2544-2558. 2558. doi:10.3201/eid3012.241042 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102324
Title
Novel Mastadenovirus Infection as Cause of Pneumonia in Imported Black-and-White Colobuses (Colobus guereza), Thailand
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
We identified a novel mastadenovirus, herein referred to as colobus adenovirus (CoAdV), as the likely cause of fatal respiratory and enteric diseases in multiple black-and-white colobuses (Colobus guereza) imported into Thailand in 2022. Among 9 affected colobuses, 4 died. Viral antigen was abundant in respiratory and enteric tissues, where prominent lesions and clinical signs were observed. We successfully cultivated CoAdV in Vero cells and characterized the complete viral genome, which indicated the virus is genetically distinct from other simian adenoviruses. We also conducted a retrospective study of archival samples from 7 other unrelated colobuses that had respiratory distress or diarrhea and found similar viral strains in 4 of those colobuses. Although we could not determine the potential harm to humans or other nonhuman primates from current information, the zoonotic and spillover potential of this virus to other related hosts should not be neglected. Veterinarians should consider CoAdV when pneumonia is diagnosed in colobuses.