Publication: Systematic Review and Meta-Analysis of Diagnostic Alzheimer’s Disease with Blood Biomarkers
Issued Date
2024
Resource Type
Resource Version
Accepted Manuscript
Language
eng
File Type
application/pdf
ISSN
2697-584X (Print)
2697-5866 (Online)
2697-5866 (Online)
Journal Title
Thai Journal of Public Health
Volume
54
Issue
2
Start Page
874
End Page
889
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Department of Biostatistics Faculty of Public Health Mahidol University
Division of Geriatric Medicine Department of Medicine Ramathibodi Hospital Mahidol University
Division of Geriatric Medicine Department of Medicine Ramathibodi Hospital Mahidol University
Bibliographic Citation
Thai Journal of Public Health. Vol. 54, No. 2 (May - Aug 2024), 874-889
Suggested Citation
Nutthida Kunsanprasit, Hathaikan Chootrakool, Saran Thanapluetiwong, Pichitpong Soontornpipit, Chukiat Viwatwongkasem Systematic Review and Meta-Analysis of Diagnostic Alzheimer’s Disease with Blood Biomarkers. Thai Journal of Public Health. Vol. 54, No. 2 (May - Aug 2024), 874-889. 889. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/109722
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Thesis
Title
Systematic Review and Meta-Analysis of Diagnostic Alzheimer’s Disease with Blood Biomarkers
Abstract
Background: One of the world's leading causes of death is Alzheimer's disease (AD). Diagnostic of the disease and determining the risk before it reaches a severe stage are essential to reduce the rate of a patient’s development into the dementia phase, as well as locating practical, economical, and effective diagnostic tools, including blood tests, are easier and still reasonably priced, compared to neuroimaging or cerebrospinal fluid (CSF) examinations.
Method: The studies were systematically searched for and determined by pooled sensitivity and specificity which studies were about diagnosing AD using the single molecular array (SIMOA) method by detecting phosphorylated tau (p-tau) in the blood. In addition, Egger's test results for heterogeneity and publication bias were evaluated.
Result: After systematically review the studies from 2016 to 2023, seven studies have been included for the meta-analysis. The results show low level of heterogeneity (I2 = 28.99%) and no publication bias Egger's test in sensitivity and specificity (p-value = 0.244 and 0.084, respectively) in patients.
Conclusion: The ability to identify p-tau in blood with SIMOA has been useful in the diagnosis of Alzheimer's disease. Currently, this procedure is utilized in conjunction with other diagnostic approaches for diagnosis.