In Silico Analysis of Inhibitor Potential of Punicalagin Compound in Pomegranate (Punica granatum) Against NS5 DENV-3 Protein
Issued Date
2024-03-06
Resource Type
ISSN
20851103
eISSN
23560991
Scopus ID
2-s2.0-105005711496
Journal Title
Indonesian Journal of Tropical and Infectious Disease
Volume
12
Issue
1
Start Page
24
End Page
34
Rights Holder(s)
SCOPUS
Bibliographic Citation
Indonesian Journal of Tropical and Infectious Disease Vol.12 No.1 (2024) , 24-34
Suggested Citation
Kautsar R., Rachmawati Y., Rokhim S., Sucipto T.H., Damayanti M., Ramadhani A.H. In Silico Analysis of Inhibitor Potential of Punicalagin Compound in Pomegranate (Punica granatum) Against NS5 DENV-3 Protein. Indonesian Journal of Tropical and Infectious Disease Vol.12 No.1 (2024) , 24-34. 34. doi:10.20473/ijtid.v12i1.52320 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/110412
Title
In Silico Analysis of Inhibitor Potential of Punicalagin Compound in Pomegranate (Punica granatum) Against NS5 DENV-3 Protein
Corresponding Author(s)
Other Contributor(s)
Abstract
Indonesia is one of the Dengue Virus (DENV) endemic areas which are dominated by DENV-2 and DENV-3. Until now, no specific drug therapy has been found to cure Dengue Virus Infection (DVI). Punicalagin is one of the active compounds that have the potential to be used as an antiviral. Unfortunately, not many studies have used punicalagin as a DENV antivirus. This study aims to determine the inhibitory potential of punicalagin compounds against NS5 DENV-3 protein through molecular docking. Molecular docking was performed using AutoDock Tools, ChemDraw, and Discovery Studio Visualizer. The target protein used is NS5 DENV-3 protein with PDB ID code: 4V0Q. The ribavirin compound was used as a positive control. The results obtained show that the punicalagin compound has the ability to attach to target receptors in the C-Terminal domain complex. This docking produces a bond free energy (ΔG) of-6.39 kcal/mol. This result is better than the ΔG of the control compound. Punicalagin's Inhibition Constant (Ki) value also showed better results than ribavirin. So it can be seen that the compound punicalagin effectively inhibits DENV replication and has the potential as a DENV drug candidate.