Tissue-specific polyphenol enrichment following oral supplementation with spray-dried Lacticaseibacillus casei-Maoberry juice in rats
Issued Date
2025-09-01
Resource Type
eISSN
2772753X
Scopus ID
2-s2.0-105012964475
Journal Title
Food Chemistry Advances
Volume
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Food Chemistry Advances Vol.8 (2025)
Suggested Citation
Chaikham P., Prangthip P., Jirasatid S. Tissue-specific polyphenol enrichment following oral supplementation with spray-dried Lacticaseibacillus casei-Maoberry juice in rats. Food Chemistry Advances Vol.8 (2025). doi:10.1016/j.focha.2025.101081 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/111690
Title
Tissue-specific polyphenol enrichment following oral supplementation with spray-dried Lacticaseibacillus casei-Maoberry juice in rats
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Corresponding Author(s)
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Abstract
Maoberry (Antidesma bunius) is a polyphenol-rich fruit with antioxidant and hepatoprotective potential. This study investigated whether co-administration with Lacticaseibacillus casei 01 could enhance in vivo polyphenol bioavailability and tissue-specific accumulation through microbial metabolism in the gut. Pasteurized Maoberry juice was supplemented with L. casei 01, spray-dried, and reconstituted daily for oral gavage in male Sprague-Dawley rats at a dose of 10<sup>11</sup>–10<sup>12</sup> CFU/kg body weight for 21 days. Rats were divided into control and probiotic-Maoberry juice powder (PM) groups (n = 7). No significant differences were observed in body weight gain or malondialdehyde levels in serum, liver, or intestine (p > 0.05), confirming the safety of the intervention and the absence of oxidative stress. Notably, liver polyphenol content significantly increased in the PM group (p ≤ 0.01), while serum and intestinal levels remained unchanged (p > 0.05). These results indicated selective hepatic accumulation of polyphenols, likely mediated by microbial biotransformation within the gut. The findings supported the potential of probiotic-Maoberry juice powder as a functional food ingredient for targeted antioxidant delivery.