Publication: Humoral immune responses to Plasmodium vivax subtelomeric transmembrane proteins in Thailand
Issued Date
2011-12-01
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ISSN
01251562
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2-s2.0-84857682398
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.42, No.6 (2011), 1313-1321
Suggested Citation
Tippawan Sungkapong, Richard Culleton, Kazuhide Yahata, Mayumi Tachibana, Ronatrai Ruengveerayuth, Rachanee Udomsangpetch, Motomi Torii, Takafumi Tsuboi, Jetsumon Sattabongkot, Osamu Kaneko, Kesinee Chotivanich Humoral immune responses to Plasmodium vivax subtelomeric transmembrane proteins in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.42, No.6 (2011), 1313-1321. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12199
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Title
Humoral immune responses to Plasmodium vivax subtelomeric transmembrane proteins in Thailand
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Abstract
Plasmodium vivax subtelomeric transmembrane protein (PvSTP) is a homolog of P. falciparum SURFIN 42 , a protein exposed on the parasite-infected erythrocyte (iE) surface, and is thus considered to be exposed on P. vivax-iE. Because antibodies targeting antigens located on the surface of P. falciparum-iE, such as P. falciparum erythrocyte membrane protein 1, play an important role in regulating the course of disease, we evaluated the presence of antibodies in P. vivax-infected patients against two PvSTP paralogs, PvSTPl and PvSTP2. Recombinant proteins corresponding to cysteine-rich domain (CRD) of the PvSTP extracellular region and the cytoplasmic region (CYT) were generated and used for the enzyme-linked immunosorb ent assay. Plasma samples (n = 70) reacted positively with recombinant PvSTP1-CRD (40%), PvSTP1-CYT (31%), PvSTP2-CRD (27%), and PvSTP2-CYT (56%), suggesting that PvSTPl and -2 are naturally immunogenic. Specific response against either PvSTP1 or PvSTP2 indicates the existence of specific antibodies for either PvSTP1 or -2.