Publication: Reversible course of pulmonary arterial hypertension related to bone marrow transplantation
Issued Date
2011-01-01
Resource Type
ISSN
16152573
09108327
09108327
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2-s2.0-84855735151
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Mahidol University
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SCOPUS
Bibliographic Citation
Heart and Vessels. Vol.26, No.5 (2011), 557-561
Suggested Citation
Alisa Limsuwan, Samart Pakakasama, Suradej Hongeng Reversible course of pulmonary arterial hypertension related to bone marrow transplantation. Heart and Vessels. Vol.26, No.5 (2011), 557-561. doi:10.1007/s00380-010-0100-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12719
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Title
Reversible course of pulmonary arterial hypertension related to bone marrow transplantation
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Abstract
Pulmonary arterial hypertension (PAH) is considered to be a rare but serious complication of bone marrow transplantation (BMT). The majority of the reports demonstrated a potential fatal outcome, while treatments are postulated to require an indefinite duration. Our objective is to describe cases of reversible PAH related to BMT in two patients. Two patients with PAH after BMT were investigated for the common secondary causes of PAH. Both results were negative. The first patient was a 19-year-old male. He was diagnosed with relapse acute lymphoblastic leukemia, underwent BMT, and developed PAH 10 months after transplantation. He was initially treated with iloprost and sildenafil. His functional class gradually improved while his medication was titrated down and switched to amlodipine. His pulmonary arterial pressure has been normalized. The second patient is a 20-year-old female, with a confirmed case of chronic myeloid leukemia, who underwent BMT and developed PAH 4 months after BMT. She was treated with sildenafil and beraprost. With improvement of her symptoms and normal exercise test, her medication was discontinued after 4 months of therapy while her pulmonary pressure currently remains normal. BMT was considered to be an uncommon cause of PAH, which is amenable to reversibility. © Springer 2010.