Publication: Extracellular free calcium and fluid secretion by the rabbit lacrimal gland in vivo
Issued Date
1979-11-01
Resource Type
ISSN
14322013
00316768
00316768
Other identifier(s)
2-s2.0-0018688781
Rights
Mahidol University
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SCOPUS
Bibliographic Citation
Pflügers Archiv European Journal of Physiology. Vol.382, No.3 (1979), 275-277
Suggested Citation
Vipa Tangkrisanavinont, Chumpol Pholpramool Extracellular free calcium and fluid secretion by the rabbit lacrimal gland in vivo. Pflügers Archiv European Journal of Physiology. Vol.382, No.3 (1979), 275-277. doi:10.1007/BF00583713 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13149
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Title
Extracellular free calcium and fluid secretion by the rabbit lacrimal gland in vivo
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Abstract
A possible role of extracellular free Ca 2+ in methacholine-induced fluid secretion in the in vivo rabbit lacrimal gland has been investigated. Lowering the extracellular Ca 2+ concentration by either intra-arterial injection or infusion of EGTA at doses which caused no systemic effects produced a dose related and reversible inhibition of methacholine-induced secretion. The inhibitory effect of EGTA was diminished when EGTA chelated with CaCl 2 in varying concentration ratios was administered. On the other hand, intra-arterial injection of CaCl 2 potentiated fluid secretion stimulated by submaximal doses of methacholine. These results suggest that fluid secretion from the rabbit lacrimal gland is dependent on the extracellular free Ca 2+ concentration. © 1979 Springer-Verlag.