Publication: A new conjugated amide-dimer from the aerial parts of Piper submultinerve
Issued Date
2012-10-01
Resource Type
ISSN
14786427
14786419
14786419
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2-s2.0-84866531554
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Mahidol University
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SCOPUS
Bibliographic Citation
Natural Product Research. Vol.26, No.19 (2012), 1824-1830
Suggested Citation
Saksit Nobsathian, Patoomratana Tuchinda, Darunee Soorukram, Manat Pohmakotr, Vichai Reutrakul, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad A new conjugated amide-dimer from the aerial parts of Piper submultinerve. Natural Product Research. Vol.26, No.19 (2012), 1824-1830. doi:10.1080/14786419.2011.639071 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13388
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Title
A new conjugated amide-dimer from the aerial parts of Piper submultinerve
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Abstract
Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using ΔTat/Rev MC99 virus and 1A2 cell line system, whereas 2 was most active (EC 50 35.1μM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC 50 50.8μM. © 2012 Copyright Taylor and Francis Group, LLC.