Publication: Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR
Issued Date
2012-09-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-84864819561
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.106, No.9 (2012), 563-566
Suggested Citation
Ampai Tanganuchitcharnchai, Lee Smythe, Michael Dohnt, Rudy Hartskeerl, Manivanh Vongsouvath, Viengmone Davong, Olay Lattana, Paul N. Newton, Stuart D. Blacksell Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.106, No.9 (2012), 563-566. doi:10.1016/j.trstmh.2012.06.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14278
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Title
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR
Abstract
The diagnostic utility of the Standard Diagnostics . Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) ≥0.75], the assay demonstrated limited diagnostic capacity with a sensitivity of 95% and a specificity of 41% compared with the . Leptospira microscopic agglutination test, which is the serological gold standard. However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%). © 2012 Royal Society of Tropical Medicine and Hygiene.