Publication: A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria
Issued Date
1988-11-01
Resource Type
ISSN
14321041
00316970
00316970
Other identifier(s)
2-s2.0-0024269429
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.35, No.6 (1988), 677-680
Suggested Citation
J. Karbwang, D. J. Back, D. Bunnag, A. M. Breckenridge A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria. European Journal of Clinical Pharmacology. Vol.35, No.6 (1988), 677-680. doi:10.1007/BF00637607 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15607
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Title
A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria
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Abstract
We have studied the kinetics of a single oral dose of mefloquine (750 mg) in 12 Thai patients with falciparum malaria and have compared the results with those of a previous study in 12 healthy Thai volunteers [6]. All the patients responded to treatment with a mean parasite clearance time of 66.6 h and a mean fever clearance time of 54.1 h. There was no significant difference in peak plasma concentration, time to peak, area under the curve or apparent volume of distribution between patients and controls. However, the terminal half-life (t 1/2 ) and mean residence time (MRT) were shorter in the patients (12.2 vs 16.7 days for t 1/2 and 15.5 vs 21.4 days for MRT). We conclude that there are changes in the disposition of mefloquine related to malaria, although the exact basis of the changes is not clear. © 1988 Springer-Verlag.