Publication: Clinical importance of antimalarial pharmacokinetics
Issued Date
1988-01-01
Resource Type
ISSN
02179687
Other identifier(s)
2-s2.0-0023807742
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asia Pacific Journal of Pharmacology. Vol.3, No.3 (1988), 181-189
Suggested Citation
J. Karbwang, N. J. White Clinical importance of antimalarial pharmacokinetics. Asia Pacific Journal of Pharmacology. Vol.3, No.3 (1988), 181-189. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15679
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Title
Clinical importance of antimalarial pharmacokinetics
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Abstract
The efficacy of an antimalarial drug depends on its specific inhibitory or cidal activity on a given species and strain of a malaria parasite. It also depends on pharmacokinetic considerations such as the speed of absorption, concentration of drug in plasma or in infected erythrocytes, distribution in tissues, clearance by metabolism and renal elimination and pharmacodynamic considerations such as toxicity. Recommendations on dosage regimens for antimalaria treatment and prophylaxis should be based on pharmacokinetic and pharmacodynamic studies performed in appropriate populations (i.e. both in volunteers and in children, adults and pregnant women with both uncomplicated and severe malaria).