Publication: Increased γδ T cells in acute Plasmodium falciparum malaria
Issued Date
1990-01-01
Resource Type
ISSN
01652478
Other identifier(s)
2-s2.0-0025090884
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Immunology Letters. Vol.25, No.1-3 (1990), 139-141
Suggested Citation
May Ho, H. Kyle Webster, Pongsri Tongtawe, Kovit Pattanapanyasat, William P. Weidanz Increased γδ T cells in acute Plasmodium falciparum malaria. Immunology Letters. Vol.25, No.1-3 (1990), 139-141. doi:10.1016/0165-2478(90)90105-Y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15970
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Title
Increased γδ T cells in acute Plasmodium falciparum malaria
Abstract
The T cell receptor γδ is normally e xpressed on a small percentage of peripheral lymphocytes. Although the role of γδ T cells in the physiologic immune response is still unknown, there is accumulating evidence that γδ T cells may participate in the immune response to mycobacterial and other infectious organisms. In this study, we have quantitated the number of circulating γδ T cells during acute Plasmodium falciparum malaria. The results indicate that γδ T cells are elevated during the acute infection and remain elevated for at least 4 weeks during convalescence. T cells may participate in the immune response against P. falciparum by functioning as non-MHC restricted cytotoxic cells against intraerythrocytic parasites. Alternatively, lymphokines may be produced on antigen stimulation which may have antiparasitic activity. © 1990.