Publication: HIV-1 drug resistance in Thailand: Before and after National Access to Antiretroviral Program
Issued Date
2005-12-01
Resource Type
ISSN
13866532
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2-s2.0-27744468980
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Virology. Vol.34, No.4 (2005), 272-276
Suggested Citation
Ruengpung Sutthent, Daungnapa Arworn, Surapol Kaoriangudom, Kulkanya Chokphaibulkit, Pongsakdi Chaisilwatana, Piyanot Wirachsilp, Vipa Thiamchai, Thaweesarp Sirapraphasiri, Sombat Tanprasertsuk HIV-1 drug resistance in Thailand: Before and after National Access to Antiretroviral Program. Journal of Clinical Virology. Vol.34, No.4 (2005), 272-276. doi:10.1016/j.jcv.2005.02.014 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16536
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Title
HIV-1 drug resistance in Thailand: Before and after National Access to Antiretroviral Program
Other Contributor(s)
Abstract
Background: The Ministry of Public Health (Thailand), MoPH, has had a program called National Access to Antiretroviral Program for People who have AIDS (PHA) or "NAPHA", to offer free antiretroviral drugs (ARV), which are locally produced in Thailand, to any HIV-1 infected patients with CD4 < 200 since 2002. This program may increase usage of ARV therapy and the emergence of HIV-1 drug resistance. Objectives: To monitor HIV-1 ARV drug resistant codon mutation in Thailand before and after the "NAPHA" program. Materials and methods: EDTA blood samples were collected from 542 HIV-1 infected subjects, who received ARV therapy in 1999 and 2001-2003, and perinatal chemoprophylaxis in 1998 and 2000. HIV-1 pol nucleotide sequences were analyzed. Results: The percentage of drug resistant detection from the ARV therapy group in 1999 and 2001-2003 were 12.14 (34/280), 10.23 (9/88), 86.96 (20/23) and 57.55 (61/106), respectively. Of 332 NRTI drug resistant codon mutation, 226 (68.07%) were thymidine analogue mutations (TAMs). The percentage of TAMs detection in 1999 and 2001-2003 were 7.14 (20/280), 9.09 (8/88), 56.52 (13/23) and 43.34 (46/106), respectively. Of 105 NNRTI drug resistant codon mutation, 95 (90.48%) were related to nevirapine drug resistance. Conclusion: Thailand may need more appropriate monitoring of drug resistance in the free ARV therapy program to protect the future usage of drugs by minimizing the emergence of drug resistance. © 2005 Elsevier B.V. All rights reserved.