Publication: Synergism of desbutyl-benflumetol and retinol against Plasmodium falciparum in vitro
Issued Date
2005-01-01
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16137671
00435325
00435325
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2-s2.0-33644834700
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Mahidol University
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SCOPUS
Bibliographic Citation
Wiener Klinische Wochenschrift. Vol.117, No.SUPPL. 4 (2005), 39-44
Suggested Citation
Doris Samal, Chaiporn Rojanawatsirivet, Gunther Wernsdorfer, Herwig Kollaritsch, Jeeraphat Sirichaisinthop, Walther H. Wernsdorfer Synergism of desbutyl-benflumetol and retinol against Plasmodium falciparum in vitro. Wiener Klinische Wochenschrift. Vol.117, No.SUPPL. 4 (2005), 39-44. doi:10.1007/s00508-005-0446-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17113
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Title
Synergism of desbutyl-benflumetol and retinol against Plasmodium falciparum in vitro
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Abstract
This in vitro study was conducted to assess the blood schizontocidal activity of Desbutyl-benflumetol (DBB), a new benzindene derivative, retinol and a combination of both compounds. The tests were carried out according to the methodology of the WHO standard test Mark II, measuring the drug-dependant inhibition of schizont maturation, and using 43 fresh isolates of Plasmodium falciparum from northwestern Thailand, an area with established multidrug-resistance. DBB and retinol showed a mean 50% effective concentration (EC-50) of 3.73 nM and 466, 86 nM and 90% effective concentration (EC-90) of 19.83 nM and 5531, 69 nM respectively. The combination of DBB and 3.50 ìM retinol showed strong inhibition of schizont maturation, with an EC-90 for DBB of 0.67 nM. At the therapeutically relevant EC-99, the combination was about 10 times more effective than expected, suggesting that retinol potentiated the effect of DBB. A concentration of 3.50 ìM retinol corresponds to the 95th percentile of the physiological serum levels. It is well known that retinol levels are significantly decreased in acute falciparum malaria. Supplementation with retinol during malaria treatment may improve the therapeutic results of blood schizontocides of the fluorene class. ©2005 Springer-Verlag.