Publication: Artemisinin-based combinations
Issued Date
2005-01-01
Resource Type
ISSN
09517375
Other identifier(s)
2-s2.0-27744541969
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Mahidol University
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SCOPUS
Bibliographic Citation
Current Opinion in Infectious Diseases. Vol.18, No.6 (2005), 531-536
Suggested Citation
Elizabeth A. Ashley, Nicholas J. White Artemisinin-based combinations. Current Opinion in Infectious Diseases. Vol.18, No.6 (2005), 531-536. doi:10.1097/01.qco.0000186848.46417.6c Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17125
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Title
Artemisinin-based combinations
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Abstract
Purpose of review: Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world. Recent findings: A large multicentre radomised trial conducted in East Asia has shown a 35% reduction in mortality from severe malaria following treatment with parenteral artesunate compared with quinine. There is increasing evidence that artemisinin-based combination treatments are safe and rapidly effective. Artemether-lumefantrine (six doses) has been shown to be very effective in large trials reported from Uganda and Tanzania. A once daily three-dose treatment of dihydroartemisinin piperaquine, a newer fixed combination, was a highly efficacious and well tolerated treatment for multi-drug resistant falciparum malaria in Southeast Asia. Summary: Early diagnosis and treatment of uncomplicated malaria with effective drugs remains a priority as part of a comprehensive malaria control strategy. Artemisinin-based combination treatments have consistently been shown to be highly effective and safe. The challenge is to make them accessible in tropical countries. © 2005 Lippincott Williams & Wilkins.