Publication:
Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment

Issued Date

1995-01-01

Resource Type

Article

ISSN

18783503
00359203

DOI

10.1016/0035-9203(95)90087-X

Other identifier(s)

2-s2.0-0028807961

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.89, No.5 (1995), 507-509

Suggested Citation

S. Krishna, S. Pukrittayakamee, W. Supanaranond, F. ter Kuile, M. Ruprah, T. Sura, N. J. White Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.89, No.5 (1995), 507-509. doi:10.1016/0035-9203(95)90087-X Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17327

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Title

Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment

Author(s)

S. Krishna
 S. Pukrittayakamee
 W. Supanaranond
 F. ter Kuile
 M. Ruprah
 T. Sura
 N. J. White

Other Contributor(s)

Mahidol University
 John Radcliffe Hospital
 Poisons Unit
 Ramathipodi Hospital

Abstract

Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use. © 1995 Oxford University Press.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/17327

Collections

Scopus 1991-2000