Publication: Serum vitamin a and β-carotene levels in pregnant women infected with human immunodeficiency virus-1
Issued Date
1996-01-01
Resource Type
ISSN
00297844
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2-s2.0-0029994554
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Mahidol University
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SCOPUS
Bibliographic Citation
Obstetrics and Gynecology. Vol.87, No.4 (1996), 564-567
Suggested Citation
Winit Phuapradit, Kamheang Chaturachinda, Surasak Taneepanichskul, Jintana Sirivarasry, Kalayanee Khupulsup Serum vitamin a and β-carotene levels in pregnant women infected with human immunodeficiency virus-1. Obstetrics and Gynecology. Vol.87, No.4 (1996), 564-567. doi:10.1016/0029-7844(95)00459-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17768
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Title
Serum vitamin a and β-carotene levels in pregnant women infected with human immunodeficiency virus-1
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Abstract
Objective: To determine if low levels of serum vitamin A and β-carotene are present in pregnant women with human immunodeficiency virus-1 (HIV-1) infection. Methods: Serum concentrations of vitamin A and β-carotene were measured in 74 pregnant women seropositive for HIV-1 infection (17 with CD4 count below 200 cells/μL) and in 148 pregnant seronegative controls in the first trimester. Comparisons were made between groups stratified by CD4 count. Results: Compared with controls, women with HIV-1 infection and CD4 count below 200 cells/μL exhibited 37% lower mean serum vitamin A levels (0.820 versus 1.308 μmol/L, P < .001) and 37% lower mean serum β-carotene levels (1.486 versus 2.362 μmol/L, P < .001). Mean maternal age, parity, gestational age, hemoglobin levels, and body mass index at entry into the study did not differ significantly between the control and HIV-1 infection groups. In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Serum β-carotene levels correlated with the percentage of CD4 lymphocytes (r = 0.407, P < .001), CD4 count (r = 0.614, P < .001), and CD4 to CD8 ratio (r = 0.434, P < .001). Conclusion: Compared with levels in uninfected women, serum vitamin A and β- carotene are decreased in HIV-1-infected pregnant women in the first trimester with CD4 counts lower than 200 cells/μL. These micronutrient concentrations also correlate with CD4 count.