Publication: Disarticulation of a knee joint in a haemophiliac with high inhibitor titre
Issued Date
1996-01-01
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ISSN
13518216
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2-s2.0-0029869748
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Mahidol University
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SCOPUS
Bibliographic Citation
Haemophilia. Vol.2, No.2 (1996), 116-119
Suggested Citation
A. Chuansumrit, P. Hathirat, S. Keorochana, P. Tardtong, P. Pintadit, Y. Rueangwetsawat, P. Isarangkura Disarticulation of a knee joint in a haemophiliac with high inhibitor titre. Haemophilia. Vol.2, No.2 (1996), 116-119. doi:10.1111/j.1365-2516.1996.tb00027.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17794
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Title
Disarticulation of a knee joint in a haemophiliac with high inhibitor titre
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Abstract
Disarticulation of a knee joint in an 8-year-old haemophilia A patient with high inhibitor of 3450 Bethesda units (BU) is described. He had an infected compound fracture of the tibia and fibula. Surgery was successfully performed after extensive plasma exchange; administration of immunosuppressive agents such as cyclophosphamide, methylprednisolone, intravenous immunoglobulin and cyclosporine were combined with a loading dose of 100 units kg-1of factor VIII concentrate, followed by continuous infusion of 16 units kg-1h-1of factor VIII in the form of factor VIII concentrate and cryoprecipitate for 7 days and decreased to 8 units kg-1h-1in the form of cryoprecipitate for 19 more days. During the 1st to 7th post-operative days, the lowest factor VIII inhibitor was 18 BU and the factor VIII level ranged from < 1-2.1 IU dL-1. On the 9th and 13th post-operative day, although the inhibitor rose to 330 and 2700 BU, respectively, there was no serious bleeding. The suture was removed on the 21st post-operative day. The inhibitor spontaneously decreased to 550, 232 and 14 BU at 1, 7 and 10 months, respectively.