Publication: Relation of haemolytic anaemia and erythrocyte-bound IgG in α- and β-thalassaemic syndromes
Issued Date
1997-04-10
Resource Type
ISSN
09024441
Other identifier(s)
2-s2.0-0030894462
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Haematology. Vol.58, No.2 (1997), 86-91
Suggested Citation
S. Chinprasertsuk, W. Wanachiwanawin, K. Pattanapanyasat, N. Tatsumi, A. Piankijagum Relation of haemolytic anaemia and erythrocyte-bound IgG in α- and β-thalassaemic syndromes. European Journal of Haematology. Vol.58, No.2 (1997), 86-91. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18143
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Title
Relation of haemolytic anaemia and erythrocyte-bound IgG in α- and β-thalassaemic syndromes
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Abstract
There has been evidence that TgG-mediated phagocytosis plays some part in destruction of erythroid cells and subsequent anaemia in thalassaemia. In this study using direct immunofluorescence and flow cytometry, erythrocyte-bound IgG was studied in 53 and 33 β-thal/Hb E and Hb H patients, respectively. The mean percentages of IgG-positive erythrocytes in both nonsplenectomized (4.4%) and splenectomized (24%) β-thal/Hb E patients were significantly higher than that in normal subjects (1.0%); p < 0.05 and < 0.001, respectively. Splenectomized β-thal/Hb E patients had significantly higher percentages of IgG-positive erythrocytes than the nonsplenectomized patients (p < 0.001). The mean percentages of IgG-positive erythrocytes in Hb H patients were comparable to those from normal controls. However, patients with α-thal 1/Hb CS had significantly higher IgG-positive erythrocytes than those with α-thal 1/α-thal 2 (p = 0.008). Splenectomized Hb H patients also had higher IgG-positive erythrocytes than nonsplenectomized Hb H patients (p < 0.039). During haemolytic crisis in some Hb H patients, high percentages of IgG-positive erythrocytes were also demonstrated. This study demonstrates the presence of increased IgG on erythrocytes in patients with β-thal/Hb E and in those with Hb H disease following splenectomy or in haemolytic crisis.