Publication: Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans
Issued Date
1998-01-01
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ISSN
13693786
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2-s2.0-0011932389
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Mahidol University
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SCOPUS
Bibliographic Citation
Medical Mycology. Vol.36, No.6 (1998), 419-424
Suggested Citation
S. Sukroongreung, K. Kitiniyom, C. Nilakul, S. Tantimavanich Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans. Medical Mycology. Vol.36, No.6 (1998), 419-424. doi:10.1046/j.1365-280X.1998.00181.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18584
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Title
Pathogenicity of basidiospores of Filobasidiella neoformans var. neoformans
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Abstract
Basidiospores of Filobasidiella neoformans var. neoformans (progeny of Cryptococcus neoformans MT 100.1 x VR 45980) were able to induce cryptococcosis in Swiss albino mice if inoculated by intraperitoneal injection, nasal instillation or nasal spraying. The latter method, with the aid of a jet nebulizer, was first adopted to imitate the natural entrance of infectious particles. Using this method the small number of basidiospores (7 x 103) could induce cryptococcosis in mice, while the higher number of the parental laboratory-grown yeast cells (1.5 x 106) did not produce infections. By nasal instillation Cyclophosphamide (Cy)-treated mice were more susceptible to the basidiospores, showing 80% cryptococcosis (eight of 10). Seven of the eight infected mice had disseminated cryptococcosis. Immunocompetent mice were more resistant to basidiospore infection than Cy-treated mice, as 40% of that group developed only pulmonary cryptococcosis; none had disseminated infection. Thus, we propose that basidiospores are one form of the infectious propagules of F. neoformans var. neoformans which can cause cryptococcosis, particularly in immunocompromised people.