Publication: Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Issued Date
2008-04-01
Resource Type
ISSN
14714922
Other identifier(s)
2-s2.0-41349093931
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Trends in Parasitology. Vol.24, No.4 (2008), 159-163
Suggested Citation
Nicholas J. White, Kasia Stepniewska, Karen Barnes, Ric N. Price, Julie Simpson Simplified antimalarial therapeutic monitoring: using the day-7 drug level?. Trends in Parasitology. Vol.24, No.4 (2008), 159-163. doi:10.1016/j.pt.2008.01.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19352
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Title
Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Abstract
The blood concentration profiles of most antimalarial drugs vary considerably between patients. The interpretation of antimalarial drug trials evaluating efficacy and effectiveness would be improved considerably if the exposure of the infecting parasite population to the antimalarial drug treatment could be measured. Artemisinin combination treatments are now recommended as first-line drugs for the treatment of falciparum malaria. Measurement of the blood, serum or plasma concentration of the slowly eliminated partner antimalarial drug on day 7 of follow-up is simpler and might be a better determinant of therapeutic response than the area under the concentration-time curve. Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials. © 2008 Elsevier Ltd. All rights reserved.