Publication: Use of a rapid immunochromatographic test for early diagnosis of dengue virus infection
Issued Date
2002-04-27
Resource Type
ISSN
09349723
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2-s2.0-0036214055
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Clinical Microbiology and Infectious Diseases. Vol.21, No.3 (2002), 224-226
Suggested Citation
L. Kittigul, K. Suankeow Use of a rapid immunochromatographic test for early diagnosis of dengue virus infection. European Journal of Clinical Microbiology and Infectious Diseases. Vol.21, No.3 (2002), 224-226. doi:10.1007/s10096-001-0691-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20213
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Title
Use of a rapid immunochromatographic test for early diagnosis of dengue virus infection
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Abstract
Acute serum samples collected from 92 patients were analysed for the presence of immunoglobulin M and G antibodies against dengue viruses using a rapid immunochromatographic (IC) test. Of 52 patients with dengue virus infection diagnosed using a standard hemagglutination inhibition test, 41 patients demonstrated dengue virus infection using the IC test. Half of the serum samples collected on day 3 after the onset of fever were positive for dengue antibodies, and all were positive on day 6 after symptom onset. In comparison with the hemagglutination inhibition test, the rapid IC test showed 79% sensitivity and 95% specificity. The efficiency of the test was 86%. The IC test showed good agreement with the hemagglutination inhibition test (k=0.72). The IC test is quick to perform and provides early diagnosis of dengue virus infection.