Publication: Comparative study of the efficacy of topical corticosteroid: Five locally made and one brand name creams
Issued Date
2002-07-01
Resource Type
ISSN
01252208
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2-s2.0-11244256575
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.85, No.7 (2002), 789-799
Suggested Citation
Siripen Puavilai, Nopadon Noppakun, Panwipa Krisadaphong, Somyot Charuwichitratana, Vichit Leenutaphong, Kanokvalai Kulthanan, Pravit Asawanonda, Porntip Huiprasert, Rutsanee Akaraphan, Pohglin Tresukosol, Tanusin Ploysangham, Suwirakorn Ophaswongse, Suwanna Ruangkarnchanasetr Comparative study of the efficacy of topical corticosteroid: Five locally made and one brand name creams. Journal of the Medical Association of Thailand. Vol.85, No.7 (2002), 789-799. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20464
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Title
Comparative study of the efficacy of topical corticosteroid: Five locally made and one brand name creams
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Abstract
The aim of this study was to evaluate the efficacy of 5 locally made clobetasol propionate creams compared with a brand name product. The study was divided into 3 parts 1) pharmacological study, 2) vasoconstriction test, and 3) double blind clinical trial. The results showed that the pharmacological properties of the locally made products were not different from the brand name product. Product C and D could diffuse through cellulose acetate membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction than the brand name product. This double blind study showed that all locally made products could improve psoriasis to the same extent as the brand name product, but there was more recurrence of psoriasis while using all the locally made products. It was concluded that locally made products were as effective as the brand name product in the treatment of psoriasis evaluated over a 2 week peroid, but more recurrence was observed with locally made products.