Publication: Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers
Issued Date
2002-04-13
Resource Type
ISSN
01616420
Other identifier(s)
2-s2.0-0036203777
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Mahidol University
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SCOPUS
Bibliographic Citation
Ophthalmology. Vol.109, No.4 (2002), 694-703
Suggested Citation
Abraham Solomon, Daniel Meller, Pinnita Prabhasawat, Thomas John, Edgar M. Espana, Klaus Peter Steuhl, Scheffer C.G. Tseng Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers. Ophthalmology. Vol.109, No.4 (2002), 694-703. doi:10.1016/S0161-6420(01)01032-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20502
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Title
Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers
Abstract
Purpose: To describe the clinical outcome of amniotic membrane transplantation (AMT) for nontraumatic corneal perforations, descemetoceles, and deep ulcers. Design: Retrospective, noncomparative, interventional case series. Participants: Thirty-four eyes of 33 consecutive patients operated on for nontraumatic corneal perforations or descemetoceles at four academic departments of ophthalmology. Associated autoimmune disorders included rheumatoid arthritis (n = 6), Stevens-Johnson syndrome (n = 3), ocular cicatricial pemphigoid (n = 2), systemic lupus erythematosus (n = 1), and one eye with Mooren's ulcer, as well as neurotrophic, or exposure keratopathy (n = 10), postinfectious nonhealing ulcers (n = 6), and postsurgery (n = 5). Intervention: Three or four layers of amniotic membrane (AM) were applied over the ulcer bed and anchored with 10-0 nylon interrupted or running sutures. A large AM piece was used as a patch to cover the entire corneal surface. Main Outcome Measures: Formation of anterior chamber depth, epithelialization of the AM grafts, and stability of the corneal stromal thickness. Results: The mean follow-up period was 8.1 ± 5.7 (ranging from 2-23) months. A successful result was observed in 28 of 34 eyes (82.3%). Of the successful cases, 23 eyes needed one AMT procedure, whereas 5 eyes needed two procedures to achieve a successful result. In five eyes, a subsequent definitive surgical procedure such as penetrating keratoplasty or lid surgery was needed. Failure was observed in six eyes with rheumatoid arthritis, neurotrophic keratopathy, or graft melting. Conclusions: AMT is an effective method for managing nontraumatic corneal perforations and descemetoceles. It can serve as either a permanent therapy or as a temporizing measure until the inflammation has subsided and a definitive reconstructive procedure can be performed. This treatment option is also beneficial in those countries where corneal tissue availability is limited. © 2002 by the American Academy of Ophthalmology.