Publication: Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets
Issued Date
2004-12-01
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ISSN
15309932
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2-s2.0-23144446951
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Mahidol University
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SCOPUS
Bibliographic Citation
AAPS PharmSciTech. Vol.5, No.1 (2004)
Suggested Citation
Srisagul Sungthongjeen, Pornsak Sriamornsak, Tasana Pitaksuteepong, Atawit Somsiri, Satit Puttipipatkhachorn Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets. AAPS PharmSciTech. Vol.5, No.1 (2004). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21060
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Title
Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets
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Abstract
The aim of this work was to assess the effect of 2 formulation variables, the pectin type (with different degrees of esterification [DEs]) and the amount of calcium, on drug release from pectin-based matrix tablets. Pectin matrix tablets were prepared by blending indomethacin (a model drug), pectin powder, and various amounts of calcium acetate and then tableting by automatic hydraulic press machine. Differential scanning calorimetry, powder x-ray diffraction, and Fourier transformed-infrared spectroscopy studies of the compressed tablets revealed no drug-polymer interaction and the existence of drug with low crystallinity. The in-vitro release studies in phosphate buffer (United States Pharmacopeia) and tris buffer indicated that the lower the DE, the greater the time for 50% of drug release (T50). This finding is probably because of the increased binding capacity of pectin to calcium. However, when the calcium was excluded, the pectins with different DEs showed similar release pattern with insignificant difference of T50. When the amount of calcium acetate was increased from 0 to 12 mg/tablet, the drug release was significantly slower. However, a large amount of added calcium (ie, 24 mg/tablet) produced greater drug release because of the partial disintegration of tablets. The results were more pronounced in phosphate buffer, where the phosphate ions induced the precipitation of calcium phosphate. In conclusion, both pectin type and added calcium affect the drug release from the pectin-based matrix tablets.