Publication:
Antimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexes

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mt-ar-supalak-2016.pdf (79.1 KB)

Issued Date

2015-12

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Article

Bibliographic Citation

EXCLI Journal. Vol.15, 2016, 144-152

Suggested Citation

Kamonrat Phopin, Nujarin Sinthupoom, Lertyot Treeratanapiboon, Sarun Kunwittaya, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul Antimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexes. EXCLI Journal. Vol.15, 2016, 144-152. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2135

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Title

Antimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexes

Author(s)

Kamonrat Phopin
 Nujarin Sinthupoom
 Lertyot Treeratanapiboon
 Sarun Kunwittaya
 Supaluk Prachayasittikul
 Somsak Ruchirawat
 Virapong Prachayasittikul

Other Contributor(s)

Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology

Abstract

8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

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Open Access article

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https://repository.li.mahidol.ac.th/handle/20.500.14594/2135

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MT-Article