Publication: Rapid human immunodeficiency virus decay in Highly Active Antiretroviral Therapy (HAART)-experienced children after starting mega-HAART
Issued Date
2004-10-01
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ISSN
0022538X
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2-s2.0-4644332772
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Virology. Vol.78, No.20 (2004), 11272-11275
Suggested Citation
Nottasorn Plipat, Ping K. Ruan, Terence Fenton, Ram Yogev Rapid human immunodeficiency virus decay in Highly Active Antiretroviral Therapy (HAART)-experienced children after starting mega-HAART. Journal of Virology. Vol.78, No.20 (2004), 11272-11275. doi:10.1128/JVI.78.20.11272-11275.2004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21354
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Title
Rapid human immunodeficiency virus decay in Highly Active Antiretroviral Therapy (HAART)-experienced children after starting mega-HAART
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Abstract
Increasing numbers of patients are treated with mega-highly active antiretroviral therapy (HAART), or multiple-combination antiretroviral therapy, in an attempt to overcome the viral resistance that has contributed to treatment failure. Studies of human immunodeficiency virus (HIV) viral dynamics are used to quantify the potency of a given regimen. While mega-HAART is expected to provide potent therapy, its potency among heavily experienced HIV-infected children who have failed previous treatment is untested. HIV dynamics studies performed in children have provided minimal information on viral dynamics during mega-HAART. The present study estimates first- and second-phase viral dynamics in six children on mega-HAART, following failure of combination therapy. The first phase of viral decay was rapid, relative to rates reported in previous pediatric studies (median δ = 0.778d-1 range = 0.583 to 1.088, half-life 1 [t11/2] = 0.894d), while the second phase revealed results similar to those of previous studies (median μ = 0.026d-1, range = -0.005 to 0.206, t21/2 = 9.316d). This indicates that mega-HAART can provide potent therapy among heavily experienced pediatric patients.