Publication: Toxicological study of pyridoxal isonicotinoyl hydrazone: Acute and subchronic toxicity
Issued Date
1991-01-01
Resource Type
ISSN
01480545
Other identifier(s)
2-s2.0-0026343885
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drug and Chemical Toxicology. Vol.14, No.4 (1991), 395-403
Suggested Citation
N. Sookvanichsilp, S. Nakornchai, W. Weerapradist Toxicological study of pyridoxal isonicotinoyl hydrazone: Acute and subchronic toxicity. Drug and Chemical Toxicology. Vol.14, No.4 (1991), 395-403. doi:10.3109/01480549109011641 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22018
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Toxicological study of pyridoxal isonicotinoyl hydrazone: Acute and subchronic toxicity
Author(s)
Other Contributor(s)
Abstract
Pyridoxal isonicotinoyl hydrazone (PIH) is a highly effective iron chelator. Acute toxicity testing was performed in mice and rats of both sexes, with 10 mice or rats/sex/group. The LDso values of PIH in both species were 5 and 1 g/kg given orally and intraperitoneally, respectively. Microscopic examination of tissues from the highest oral dose (6 g/kg) animals that survived 7 days revealed fatty degeneration in the liver. Subchronic toxicity was tested in rats of both sexes, with 8 males and 8 females/group. PIH doses of 100, 400 and 800 mg/kg were given orally for 90 consecutive days. Water was given to the control group. Hematocrit and blood chemistries were analysed at weeks 3, 6, 10 and 13. There were no changes in hematocrit and BUN. PIH at doses of 800 mg/kg caused a significant increase in serum alkaline phosphatase and transaminase levels at week 13. Microscopic examination showed hepatic degeneration in a dose-related fashion. Vascular congestion of the kidney and spleen was also found. No histopathological changes were detected in sections from the stomach and intestine. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.