Publication:
Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study

Issued Date

1993-01-01

Resource Type

Article

ISSN

10970215
00207136

DOI

10.1002/ijc.2910550211

Other identifier(s)

2-s2.0-0027365919

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

International Journal of Cancer. Vol.55, No.2 (1993), 228-236

Suggested Citation

Geoffrey Berry, Robert Maclennan, Rodney Shearman, Tatiana Jelihovsky, Joan Cooper Booth, Ramiro Molina, Luis Martinez, Oriana Salas, Alfredo Dabancens, Chen Zhiheng, Tao Yun, Hu Yong Wei, Alvaro Cuadros, Nubia Aristizabal, Baruch Modan, Elaine Ron, Esther Alfandary, J. G. Mati, Patrick Kenya, Alfred Kungu, D. Gatei, Hector Rodriguez Cuevas, Socorro Benavides Salazar, Antonio Palet, Patricia Ontiveros, Pat A. Ibeziako, T. A. Junaid, P. Aghediuno, A. A. Abioye, Ruben A. Apelo, Julietta R. De la Cruz, Jose Baens, Benjamin D. Canlas, Suporn Silpisornkosol, Tieng Pardthaisong, Viruch Charoeniam, Choti Theetranont, Banpot Boosiri, Supawat Chutivongse, Pramuan Virutamasen, Chansuda Wongsrichanalai, Sermsri Sindhavananda, Suporn Koetsawang, Duangdao Rachawat, Amorn Koetsawang, Gustave Riotton, William M. Christopherson, Joseph L. Melnick, Ervin Adam, David B. Thomas, Roberta M. Ray, Elizabeth A. Noonan, Janet L. Stanford, Karin A. Rosenblatt, Susan Holck, Olav Meirik, Timothy M.M. Farley, David B. Thomas, Roberta M. Ray Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study. International Journal of Cancer. Vol.55, No.2 (1993), 228-236. doi:10.1002/ijc.2910550211 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22560

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Title

Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study

Author(s)

Geoffrey Berry
 Robert Maclennan
 Rodney Shearman
 Tatiana Jelihovsky
 Joan Cooper Booth
 Ramiro Molina
 Luis Martinez
 Oriana Salas
 Alfredo Dabancens
 Chen Zhiheng
 Tao Yun
 Hu Yong Wei
 Alvaro Cuadros
 Nubia Aristizabal
 Baruch Modan
 Elaine Ron
 Esther Alfandary
 J. G. Mati
 Patrick Kenya
 Alfred Kungu
 D. Gatei
 Hector Rodriguez Cuevas
 Socorro Benavides Salazar
 Antonio Palet
 Patricia Ontiveros
 Pat A. Ibeziako
 T. A. Junaid
 P. Aghediuno
 A. A. Abioye
 Ruben A. Apelo
 Julietta R. De la Cruz
 Jose Baens
 Benjamin D. Canlas
 Suporn Silpisornkosol
 Tieng Pardthaisong
 Viruch Charoeniam
 Choti Theetranont
 Banpot Boosiri
 Supawat Chutivongse
 Pramuan Virutamasen
 Chansuda Wongsrichanalai
 Sermsri Sindhavananda
 Suporn Koetsawang
 Duangdao Rachawat
 Amorn Koetsawang
 Gustave Riotton
 William M. Christopherson
 Joseph L. Melnick
 Ervin Adam
 David B. Thomas
 Roberta M. Ray
 Elizabeth A. Noonan
 Janet L. Stanford
 Karin A. Rosenblatt
 Susan Holck
 Olav Meirik
 Timothy M.M. Farley
 David B. Thomas
 Roberta M. Ray

Other Contributor(s)

The University of Sydney
 Hospital Jose Joaquin Aguirre
 Shanghai Institute of Planned Parenthood Research
 Hospital Universitario
 Chaim Sheba Medical Center Israel
 University of Nairobi
 Hospital General de Mexico
 University of Ibadan
 University of the Philippines Manila
 Chiang Mai University
 Chulalongkorn University
 Mahidol University
 Universite de Geneve Faculte de Medecine
 University of Louisville Health Sciences Center
 Baylor College of Medicine
 Fred Hutchinson Cancer Research Center
 Organisation Mondiale de la Sante
 Hospital del Salvador

Abstract

Data from a hospital‐based case‐control study collected in 11 participating centers in 9 countries were analyzed to determine whether use of combined oral contraceptives alters risk of invasive squamous‐cell cervical cancer. Information on prior use of oral contraceptives, screening for cervical cancer, and suspected risk factors for this disease were ascertained from interviews of 2361 cases and 13,644 controls. A history of smoking and anal and genital warts was obtained, and blood specimens were collected for measurement of antibodies against herpes simplex and cytomegalo viruses, from selected sub‐sets of these women, as was a sexual history from interviews of husbands. The relative risk of invasive squamous‐cell cervical carcinoma was estimated to be 1.31, with a 95% confidence interval that excluded one, in women who ever used combined oral contraceptives. Risk of this disease increased significantly with duration of use after 4 to 5 years from first exposure, and declined with the passage of time after cessation of use to that of non‐users in about 8 years. No sources of bias or confounding were identified that offered plausible explanations for these findings. The strength of these results, and their consistency with those from other studies, suggest that a causal relationship may exist between use of combined oral contraceptives and squamous‐cell cervical carcinoma. Women who have used these products for 4 or more years, and who most recently used them within the past 8 years, should receive high priority for cervical cytologic screening. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/22560

Collections

Scopus 1991-2000