Publication: Tissue tropism of a Thailand strain of high-pathogenicity avian influenza virus (H5N1) in tissues of naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anas spp.)
Issued Date
2006-06-01
Resource Type
ISSN
14653338
03079457
03079457
Other identifier(s)
2-s2.0-33745035929
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Mahidol University
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SCOPUS
Bibliographic Citation
Avian Pathology. Vol.35, No.3 (2006), 250-253
Suggested Citation
Chongmas Antarasena, Rungtiva Sirimujalin, Porntip Prommuang, Stuart D. Blacksell, Naruepol Promkuntod, Praison Prommuang Tissue tropism of a Thailand strain of high-pathogenicity avian influenza virus (H5N1) in tissues of naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anas spp.). Avian Pathology. Vol.35, No.3 (2006), 250-253. doi:10.1080/03079450600714510 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22893
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Title
Tissue tropism of a Thailand strain of high-pathogenicity avian influenza virus (H5N1) in tissues of naturally infected native chickens (Gallus gallus), Japanese quail (Coturnix coturnix japonica) and ducks (Anas spp.)
Abstract
The tropism of a Thailand strain of highly pathogenic avian influenza H5N1 virus was demonstrated on tissues (lung, trachea, heart, liver, spleen, pancreas, rectum, kidney, brain, skeletal muscle, duodenum, and oviduct) from naturally infected native chickens ( Gallus gallus ), Japanese quail ( Coturnix coturnix japonica ) and ducks ( Anas spp.) by indirect immunofluorescence assay. In chickens and quail, the distribution and localization of nucleoprotein viral antigen was similar and detected at the highest level in cardiac myocytes, at 88% (chickens) and 89% (quail), and respiratory, digestive and urinary systems all showed high levels of antigen. Antigen in duck tissues were detected at significantly lower levels (P < 0.05) with the exception of brain and skeletal muscle samples. In most cases, antigen in duck tissue was absent in the digestive organs but present in respiratory organs, which supports the hypothesis that aerosol and oral-oral transmission are the main method of highly pathogenic avian influenza virus transmission from this species. © 2006 Houghton Trust Ltd.