Publication: Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1
Issued Date
2007-06-01
Resource Type
ISSN
01252208
01252208
01252208
Other identifier(s)
2-s2.0-34347333276
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.90, No.6 (2007), 1123-1128
Suggested Citation
Ananya Manuyakorn, Tawesak Tanwandee, Kanit Atisook Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1. Journal of the Medical Association of Thailand. Vol.90, No.6 (2007), 1123-1128. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24849
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Pathologically different features and fibrosis scores in chronic hepatitis C genotypes 3 and 1
Author(s)
Other Contributor(s)
Abstract
Background: Chronic hepatitis C genotypes 3 and 1 are the two most common genotypes in Thailand. Objective: Identify the pathologically different features between genotypes 3 and 1and to compare the fibrosis score of Knodell HAI and Ishak modified HAI. Material and method: The pathological features of 114 liver biopsies were evaluated. Results: Steatosis was more commonly found in genotype 3 than in genotype 1 (97.1% vs. 77.8%, p = 0.001). Portal lymphoid follicles were commonly found, but bile duct damage was uncommon. The majority of portal tracts showed partial involvement. The majority of patients had Knodell fibrosis 1 and Ishak fibrosis 3. Conclusion: Steatosis is significantly more common in genotype 3, while other features do not show any differences. The portal tracts show partial involvement because inflammatory cells tend to aggregate and form lymphoid follicles. The most comparable fibrosis scores are Knodell fibrosis 1 and Ishak fibrosis 3.