Publication: Detection and structural analysis of abnormal hemoglobins found in Thailand
Issued Date
1999-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0033301445
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.SUPPL. 2 (1999), 88-93
Suggested Citation
Jisnuson Svasti, Chantragan Srisomsap, Prance Winichagoon, Suthat Fucharoen Detection and structural analysis of abnormal hemoglobins found in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.30, No.SUPPL. 2 (1999), 88-93. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25555
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Title
Detection and structural analysis of abnormal hemoglobins found in Thailand
Abstract
In Thailand, some 20 different abnormal hemoglobins have been found in the last 30 years. Most are rare except tor Hb E and Hb Constant Spring, found with frequencies of 10-53% and 1-8% respectively in different parts of the country. Most mutations are point mutations, but C-terminal elongations and crossing-over arc also found. Most mutations do not cause clinical problems, but some can give rise to mild thalassemia syndromes, or cause problems in association with thalassemia. Abnormal hemoglobins may often be diagnosed by electrophoresis, but some variants have the same mobility, so that other techniques are required, such as HPLC and the use of allele-specific polymerase reaction or oligonucleotide probes . Novel variants, not previously described in Thailand, require structural analysis at the protein and DNA level.