Publication: Intrapulmonary pharmacokinetics of ofloxacin in drug-resistant tuberculosis
Issued Date
2001-05-14
Resource Type
ISSN
10273719
Other identifier(s)
2-s2.0-0035042657
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Tuberculosis and Lung Disease. Vol.5, No.3 (2001), 278-282
Suggested Citation
N. Chierakul, D. Klomsawat, S. Chulavatnatol, B. Chindavijak Intrapulmonary pharmacokinetics of ofloxacin in drug-resistant tuberculosis. International Journal of Tuberculosis and Lung Disease. Vol.5, No.3 (2001), 278-282. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26786
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Title
Intrapulmonary pharmacokinetics of ofloxacin in drug-resistant tuberculosis
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Abstract
OBJECTIVE: To determine the lung epithelial lining fluid (ELF) and serum levels of ofloxacin in drug-resistant tuberculosis patients during treatment. DESIGN: Ten drug-resistant tuberculosis patients treated with ofloxacin containing regimens for at least 2 weeks were enrolled in the study. Subjects ingested ofloxacin 10 mg/kg and other anti-tuberculosis agents after overnight fasting. RESULTS: Serum and bronchoalveolar lavage fluid were collected at 4 hours after treatment and assayed by high performance liquid chromatography. The mean concentrations of ofloxacin in serum and ELF were 5.889 ± 1.096 and 16.583 ± 8.697 mg/L, respectively. The mean ratio of ELF-to-serum ofloxacin concentration was 2.825 ± 1.275. CONCLUSION: Ofloxacin can penetrate well into the intra-alveolar fluid of patients treated for drug-resistant tuberculosis. The lung ELF concentrations were consistently higher than the minimal inhibitory concentrations of Mycobacterium tuberculosis as determined in vitro.