Publication: Constituents and bioactivities of Clausena excavata
Issued Date
2009-07-29
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03855414
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2-s2.0-67651114125
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Mahidol University
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SCOPUS
Bibliographic Citation
Heterocycles. Vol.79, No.C (2009), 121-144
Suggested Citation
Ngampong Kongkathip, Boonsong Kongkathip Constituents and bioactivities of Clausena excavata. Heterocycles. Vol.79, No.C (2009), 121-144. doi:10.3987/REV-08-SR(D)2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27409
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Title
Constituents and bioactivities of Clausena excavata
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Abstract
Clausena excavata Burm. f. (Rutaceae) is a medicinal plant which is used in folklore medicine for treatment of cold, malaria, AIDS, dermatopathy, abdominal pain, and snake-bite. This plant is a rich source of coumarins and carbazole alkaloids. So far, fifty-three coumarins and fifty-eight carbazole alokaloids were isolated from C. excavata. Furthermore, a small group of tetranortriterpenoids, steroids, flavonoids, and essential oils were also obtained from this plant. C. excavata showed diverse therapeutic activities which are antibacterial, antifungal, antiplatelet, antiplasmodial, antitumor, antinociceptive, immunomodulatory, antimycobacterial, and anti-HIV-1 activities. The incidence of HIV-1 infection leading to AIDS has increased every year, and fungal and bacterial infections, particularly TB-causing mycobacteria are prevalent in HIV-infected patients. So Clausena excavata which showed inhibition of these diseases, is very promising to be developed for treatment of AIDS. © 2009 The Japan Institute of Heterocyclic Chemistry All rights reserved.