Publication: Wasp venom peptides may play a role in the pathogenesis of acute disseminated encephalomyelitis in humans: A structural similarity analysis
Issued Date
2009-12-01
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ISSN
20103778
2010376X
2010376X
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2-s2.0-78651552020
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Mahidol University
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SCOPUS
Bibliographic Citation
World Academy of Science, Engineering and Technology. Vol.36, (2009), 493-497
Suggested Citation
Permphan Dharmasaroja Wasp venom peptides may play a role in the pathogenesis of acute disseminated encephalomyelitis in humans: A structural similarity analysis. World Academy of Science, Engineering and Technology. Vol.36, (2009), 493-497. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27535
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Title
Wasp venom peptides may play a role in the pathogenesis of acute disseminated encephalomyelitis in humans: A structural similarity analysis
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Abstract
Acute disseminated encephalomyelitis (ADEM) has been reported to develop after a hymenoptera sting, but its pathogenesis is not known in detail. Myelin basic protein (MBP)- specific T cells have been detected in the blood of patients with ADEM, and a proportion of these patients develop multiple sclerosis (MS). In an attempt to understand the mechanisms underlying ADEM, molecular mimicry between hymenoptera venom peptides and the human immunodominant MBP peptide was scrutinized, based on the sequence and structural similarities, whether it was the root of the disease. The results suggest that the three wasp venom peptides have low sequence homology with the human immunodominant MBP residues 85-99. Structural similarity analysis among the three venom peptides and the MS-related HLA-DR2b (DRA, DRB1*1501)-associated immunodominant MHC binding/TCR contact residues 88-93, VVHFFK showed that hyaluronidase residues 7-12, phospholipase A1 residues 98-103, and antigen 5 residues 109-114 showed a high degree of similarity 83.3%, 100%, and 83.3% respectively. In conclusion, some wasp venom peptides, particularly phospholipase A1, may potentially act as the molecular motifs of the human 3HLA-DR2b-associated immunodominant MBP88-93, and possibly present a mechanism for induction of wasp sting-associated ADEM.