Publication:
Clinical impact of methicillin resistance on outcome of patients with Staphylococcus aureus infection: A stratified analysis according to underlying diseases and sites of infection in a large prospective cohort

Issued Date

2010-10-01

Resource Type

Article

ISSN

01634453

DOI

10.1016/j.jinf.2010.07.011

Other identifier(s)

2-s2.0-77956652604

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Infection. Vol.61, No.4 (2010), 299-306

Suggested Citation

Cheol In Kang, Jae Hoon Song, Doo Ryeon Chung, Kyong Ran Peck, Kwan Soo Ko, Joon Sup Yeom, Shin Woo Kim, Hyun Ha Chang, Yeon Sook Kim, Sook In Jung, Jun Seong Son, Po Ren Hsueh, Thomas Man kit So, M. K. Lalitha, Yonghong Yang, Shao Guang Huang, Hui Wang, Quan Lu, Celia C. Carlos, Jennifer A. Perera, Cheng Hsun Chiu, Jien Wei Liu, Anan Chongthaleong, Visanu Thamlikitkul, Hung Van Pham Clinical impact of methicillin resistance on outcome of patients with Staphylococcus aureus infection: A stratified analysis according to underlying diseases and sites of infection in a large prospective cohort. Journal of Infection. Vol.61, No.4 (2010), 299-306. doi:10.1016/j.jinf.2010.07.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29529

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Title

Clinical impact of methicillin resistance on outcome of patients with Staphylococcus aureus infection: A stratified analysis according to underlying diseases and sites of infection in a large prospective cohort

Author(s)

Cheol In Kang
 Jae Hoon Song
 Doo Ryeon Chung
 Kyong Ran Peck
 Kwan Soo Ko
 Joon Sup Yeom
 Shin Woo Kim
 Hyun Ha Chang
 Yeon Sook Kim
 Sook In Jung
 Jun Seong Son
 Po Ren Hsueh
 Thomas Man kit So
 M. K. Lalitha
 Yonghong Yang
 Shao Guang Huang
 Hui Wang
 Quan Lu
 Celia C. Carlos
 Jennifer A. Perera
 Cheng Hsun Chiu
 Jien Wei Liu
 Anan Chongthaleong
 Visanu Thamlikitkul
 Hung Van Pham

Other Contributor(s)

SungKyunKwan University, School of Medicine
 Kyungpook National University Hospital
 Chonnam National University
 Chonnam National University, College of Medicine
 Kyung Hee Medical Center
 National Taiwan University Hospital
 Princess Margaret Hospital Hong Kong
 Christian Medical College, Vellore
 Capital Medical University China
 Shanghai Jiao Tong University School of Medicine
 Peking Union Medical College
 Shanghai Jiao Tong University
 Gokila
 University of Colombo
 Chang Gung University College of Medicine
 Asia Pacific Foundation for Infectious Diseases (APFID)
 Mahidol University
 University of Medicine and Pharmacy
 Madras Medical Mission

Abstract

Objective: This study was conducted to identify the predictors of mortality and to evaluate the impact of methicillin resistance on outcome in patients with . Staphylococcus aureus infection according to underlying conditions and type of infection. Methods: An observational cohort study including 4949 patients with . S. aureus infection was conducted. We compared data from patients with MRSA infection with those with MSSA infection. Results: The 30-day mortality rate of MRSA group was significantly higher than that of MSSA group (15.6% vs. 6.2%, . P < 0.001). However, MRSA infection was not found to be independent risk factor for mortality after adjusting for other variables (OR = 1.03, 95% CI = 0.80-1.32). When we analyzed patients with . S. aureus bacteremia (n = 709), MRSA infection was found to be significantly associated with mortality in multivariate analysis (Adjusted OR = 1.69, 95% CI = 1.15-2.49). When the 30-day mortality rates were compared according to underlying diseases, the 30-day mortality rate of MRSA group was significantly higher than that of MSSA group in patients with malignancy or renal diseases. MRSA infection was also found to be one of the independent risk factors for mortality in patients with malignancy (adjusted OR = 1.69, 95% CI = 1.06-2.70) and in those with renal disease (adjusted OR = 1.70, 95% CI = 1.0-2.89), after adjustment for host variables. Conclusions: Methicillin resistance adversely affected the outcome of patients with . S. aureus infection, in patients with cancer or renal disease and in those with . S. aureus bacteremia, although MRSA infection was not found to be significantly associated with higher mortality in overall patient population. © 2010 The British Infection Society.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/29529

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Scopus 2006-2010