Publication: Quinine loading dose in cerebral malaria
Issued Date
1983-01-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0020674725
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.32, No.1 (1983), 1-5
Suggested Citation
N. J. White, S. Looareesuwan, D. A. Warrell, M. J. Warrell, P. Chanthavanich, D. Bunnag, T. Harinasuta Quinine loading dose in cerebral malaria. American Journal of Tropical Medicine and Hygiene. Vol.32, No.1 (1983), 1-5. doi:10.4269/ajtmh.1983.32.1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30478
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Quinine loading dose in cerebral malaria
Other Contributor(s)
Abstract
In cerebral malaria, the use of currently recommended doses of intravenous quinine may results in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.