Publication: Analysis of DNA from various species and strains of malaria parasites by restriction endonuclease fingerprinting
Issued Date
1983-01-01
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ISSN
03050491
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2-s2.0-0020667150
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Mahidol University
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SCOPUS
Bibliographic Citation
Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.74, No.3 (1983), 481-485
Suggested Citation
S. Tungpradabkul, S. Panyim, P. Wilairat, Y. Yuthavong Analysis of DNA from various species and strains of malaria parasites by restriction endonuclease fingerprinting. Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.74, No.3 (1983), 481-485. doi:10.1016/0305-0491(83)90214-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30512
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Title
Analysis of DNA from various species and strains of malaria parasites by restriction endonuclease fingerprinting
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Abstract
1. 1. DNA from various rodent Plasmodium species and strains and from P. falciparum, the human parasite, were analysed by agarose gel electrophoresis following digestion with restriction endonucleases EcoRI, Hind III and Bam H1. Complex patterns of ethidium-stained bands were obtained, which showed similarity but reproducible differences among the various parasite species (P. chabaudi, P. yoelii, P. berghei and P. falciparum). 2. 2. No differences could be discerned among two cloned strains of P. yoelii (33X, and YM) and among pyrimethamine-resistant (pyrimethamine + chloroquine)-resistant and the drug-sensitive P. chabaudi clone from which the resistant clones were derived. 3. 3. From the known complexity of Plasmodium DNA it could be concluded that the visible bands were derived from repetitive DNA fractions. © 1983.