Publication: Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease
Issued Date
2013-05-03
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ISSN
18755828
15672050
15672050
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2-s2.0-84876840818
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Mahidol University
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SCOPUS
Bibliographic Citation
Current Alzheimer Research. Vol.10, No.3 (2013), 252-260
Suggested Citation
Jae K. Ryu, Jonathan P. Little, Andis Klegeris, Nattinee Jantaratnotai, James G. McLarnon Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease. Current Alzheimer Research. Vol.10, No.3 (2013), 252-260. doi:10.2174/1567205011310030004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32346
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Title
Actions of the anti-angiogenic compound angiostatin in an animal model of Alzheimer's disease
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Abstract
We have examined the anti-angiogenic compound, angiostatin as a modulator of inflammatory reactivity and vascular responses and for neuroprotection in an animal model of Alzheimer's disease (AD). Intra-hippocampal amyloidbeta (Aβ1-42) injection, relative to controls phosphate buffer saline (PBS) or reverse peptide Aβ42-1, increased gliosis in the molecular layer (ML) of rat hippocampus. Vascular remodeling was indicated from increased microvessel immunoreactivity (ir) in ML suggesting the possibility of an angiogenic response to peptide injection. Administration of Aβ1-42 also induced a loss of neurons in the granule cell region of hippocampus relative to controls. Treatment of peptide-injected rats with angiostatin was associated with a spectrum of modulatory effects including reduced microgliosis (by 34%), diminished microvessel ir (by 36%) and increased neuronal viability (by 31%) compared with peptide injection alone. Angiostatin treatment was ineffective in reducing astrogliosis induced by Aβ1-42 and applied alone the compound had no significant effect to alter gliosis, microvessel ir or neuronal viability compared with PBS control. In vitro, angiostatin significantly attenuated secretion of the pro-angiogenic agent, vascular endothelial growth factor (VEGF) in lipopolysaccharide (LPS)-stimulated THP-1 cells. Our findings provide novel evidence for a broad spectrum of angiostatin effects in an animal model of AD including actions to reduce inflammatory reactivity, stabilize vascular remodeling and confer neuroprotection. The overall effects of angiostatin are consistent with actions of the compound to inhibit microglial secretion of VEGF. © 2013 Bentham Science Publishers.