Publication: Chromosome-centric human proteome project (C-HPP): Chromosome 12
Issued Date
2014-07-03
Resource Type
ISSN
15353907
15353893
15353893
Other identifier(s)
2-s2.0-84903750474
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Proteome Research. Vol.13, No.7 (2014), 3160-3165
Suggested Citation
Sakdithep Chaiyarit, Nilubon Singhto, Yi Ju Chen, Chia Ying Cheng, Wararat Chiangjong, Rattiyaporn Kanlaya, Henry H.N. Lam, Paleerath Peerapen, Ting Yi Sung, Phornpimon Tipthara, Akhilesh Pandey, Terence C.W. Poon, Yu Ju Chen, Ravi Sirdeshmukh, Maxey C.M. Chung, Visith Thongboonkerd Chromosome-centric human proteome project (C-HPP): Chromosome 12. Journal of Proteome Research. Vol.13, No.7 (2014), 3160-3165. doi:10.1021/pr500009j Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33246
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Chromosome-centric human proteome project (C-HPP): Chromosome 12
Other Contributor(s)
Mahidol University
Institute of Chemistry Academia Sinica Taiwan
Institute of Information Science Academia Sinica Taiwan
Hong Kong University of Science and Technology
Institute of Bioinformatics
The Johns Hopkins School of Medicine
Prince of Wales Hospital Hong Kong
National University of Singapore
Yong Loo Lin School of Medicine
Institute of Chemistry Academia Sinica Taiwan
Institute of Information Science Academia Sinica Taiwan
Hong Kong University of Science and Technology
Institute of Bioinformatics
The Johns Hopkins School of Medicine
Prince of Wales Hospital Hong Kong
National University of Singapore
Yong Loo Lin School of Medicine
Abstract
Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP). © 2014 American Chemical Society.