Publication: Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin
Issued Date
2014-01-01
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ISSN
10959319
00262862
00262862
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2-s2.0-84901236284
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Mahidol University
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SCOPUS
Bibliographic Citation
Microvascular Research. Vol.93, (2014), 72-79
Suggested Citation
Kanjana Jittiporn, Jutamas Suwanpradid, Chintan Patel, Modesto Rojas, Suwan Thirawarapan, Primchanien Moongkarndi, Wisuda Suvitayavat, Ruth B. Caldwell Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin. Microvascular Research. Vol.93, (2014), 72-79. doi:10.1016/j.mvr.2014.03.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33425
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Title
Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin
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Abstract
Retinal neovascularization is a major cause of vision loss in diseases characterized by retinal ischemia and is characterized by the pathological growth of abnormal vessels. Vascular endothelial growth factor (VEGF) is known to play an important role in this process. Oxidative stress has been strongly implicated in up-regulation of VEGF associated with neovascularization in various tissues. Hence, compounds with anti-oxidant actions can prevent neovascularization. α-Mangostin, a component of mangosteen (. Garcinia mangostana Linn), has been shown to have an anti-oxidant property in pathological conditions involving angiogenesis such as cancer. However, the effect of α-mangostin on ROS formation and angiogenic function in microvascular endothelial cells has not been studied. Hence, this study demonstrated the anti-angiogenic effects of α-mangostin in relation to ROS formation in bovine retinal endothelial cells (REC). α-Mangostin significantly and dose-dependently reduced formation of ROS in hypoxia-treated REC. α-Mangostin also significantly and dose-dependently suppressed VEGF-induced increases in permeability, proliferation, migration and tube formation in REC and blocked angiogenic sprouting in the ex vivo aortic ring assay. In addition, α-mangostin inhibited VEGF-induced phosphorylation of VEGFR2 and ERK1/2-MAPK. According to our results, α-mangostin reduces oxidative stress and limits VEGF-induced angiogenesis through a process involving abrogation of VEGFR2 and ERK1/2-MAPK activation. © 2014 Elsevier Inc.