Publication: Lack of association between high-risk human papillomaviruses and oral squamous cell carcinoma in young Japanese patients
Issued Date
2014-01-01
Resource Type
ISSN
2476762X
15137368
15137368
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2-s2.0-84903534243
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.15, No.10 (2014), 4135-4141
Suggested Citation
Pradit Rushatamukayanunt, Kei Ichi Morita, Sho Matsukawa, Hiroyuki Harada, Hiroaki Shimamoto, Hirofumi Tomioka, Ken Omura Lack of association between high-risk human papillomaviruses and oral squamous cell carcinoma in young Japanese patients. Asian Pacific Journal of Cancer Prevention. Vol.15, No.10 (2014), 4135-4141. doi:10.7314/APJCP.2014.15.10.4135 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33445
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Title
Lack of association between high-risk human papillomaviruses and oral squamous cell carcinoma in young Japanese patients
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Abstract
Background: Human papillomaviruses (HPV) may play an important role as one of the possible etiologies of oral squamous cell carcinoma (OSCC). The present study aimed to investigate the association between HPV and OSCC in young Japanese patients by examining the presence of HPV DNA and surrogate markers in OSCC tissues. Materials and Methods: Forty young patients with OSCC whose surgical specimens were available were analyzed and compared with 40 patients randomly recruited from a pool of patients aged >40 years. HPV DNA was detected using the polymerase chain reaction-based AMPLICOR® HPV test, and surrogate markers of HPV infection were analyzed using immunohistochemical techniques to detect p16INK4a and p53. Results: Only two (5%) young patients and one (2.5%) older patient were positive for HPV DNA. p16INK4a overexpression was identified in six (15%) young patients. p53 staining levels were not high in tissues of most young patients (27 patients, 67.5%). HPV DNA status did not significantly correlate with p16INK4a expression levels. Profiles of increased levels of p16INK4a expression with diminished levels of p53 staining were not associated with the presence of HPV DNA. The combined p53 with p16INK4a profiles were significantly correlated with alcohol consumption in younger patients (p=0.006). Conclusions: Results of the present study indicate that HPV is less likely to cause OSCC in young Japanese patients, and the p16INK4a expression level is not an appropriate surrogate marker for HPV infection in OSCC.