Publication: Polyethylenimine-immobilized core-shell nanoparticles: Synthesis, characterization, and biocompatibility test
Issued Date
2014-01-01
Resource Type
ISSN
09284931
Other identifier(s)
2-s2.0-84889087499
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Materials Science and Engineering C. Vol.34, No.1 (2014), 377-383
Suggested Citation
Montri Ratanajanchai, Sunhapas Soodvilai, Nuttaporn Pimpha, Panya Sunintaboon Polyethylenimine-immobilized core-shell nanoparticles: Synthesis, characterization, and biocompatibility test. Materials Science and Engineering C. Vol.34, No.1 (2014), 377-383. doi:10.1016/j.msec.2013.09.037 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33903
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Polyethylenimine-immobilized core-shell nanoparticles: Synthesis, characterization, and biocompatibility test
Abstract
Herein, we prepared PEI-immobilized core-shell particles possessing various types of polymer cores via a visible light-induced surfactant-free emulsion polymerization (SFEP) of three vinyl monomers: styrene (St), methyl methacrylate (MMA), and 2-hydroxyethyl methacrylate (HEMA). An effect of monomers on the polymerization and characteristics of resulting products was investigated. Monomers with high polarity can provide high monomer conversion, high percentage of grafted PEI, stable particles with uniform size distribution but less amino groups per particles. All prepared nanoparticles exhibited a core-shell nanostructure, containing PEI on the shell with hydrodynamic size around 140-230 nm. For in-vitro study in Caco-2 cells, we found that the incorporation of PEI into these core-shell nanoparticles can significantly reduce its cytotoxic effect and also be able to internalized within the cells. Accordingly, these biocompatible particles would be useful for various biomedical applications, including gene transfection and intracellular drug delivery. © 2013 Elsevier B.V.