Publication: Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria
Issued Date
2014-01-01
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ISSN
00029637
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2-s2.0-84902250846
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.90, No.6 (2014), 1117-1123
Suggested Citation
Jiraporn Laothamatas, Christina L. Sammet, Xavier Golay, Marc Van Cauteren, Varinee Lekprasert, Noppadon Tangpukdee, Srivicha Krudsood, Wattana Leowattana, Polrat Wilairatana, Srirama V. Swaminathan, Robert L. DeLaPaz, Truman R. Brown, Sornchai Looareesuwan, Gary M. Brittenham Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene. Vol.90, No.6 (2014), 1117-1123. doi:10.4269/ajtmh.13-0665 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34105
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Title
Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria
Abstract
Patients with acute uncomplicated Plasmodium falciparum malaria have no evident neurologic disorder, vital organ dysfunction, or other severe manifestations of infection. Nonetheless, parasitized erythrocytes cytoadhere to the endothelium throughout their microvasculature, especially within the brain. We aimed to determine if 3 Tesla magnetic resonance imaging studies could detect evidence of cerebral abnormalities in these patients. Within 24 hours of admission, initial magnetic resonance imaging examinations found a lesion with restricted water diffusion in the mid-portion of the splenium of the corpus callosum of 4 (40%) of 10 male patients. The four patients who had a splenial lesion initially had evidence of more severe hemolysis and thrombocytopenia than the six patients who had no apparent abnormality. Repeat studies four weeks later found no residua of the lesions and resolution of the hematologic differences. These observations provide evidence for acute cerebral injury in the absence of severe or cerebral malaria. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.