Publication:
Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination

Issued Date

2014-03-19

Resource Type

Article

ISSN

19466242
19466234

DOI

10.1126/scitranslmed.3007730

Other identifier(s)

2-s2.0-84899087118

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Science Translational Medicine. Vol.6, No.228 (2014)

Suggested Citation

Nicole L. Yates, Hua Xin Liao, Youyi Fong, Allan DeCamp, Nathan A. Vandergrift, William T. Williams, S. Munir Alam, Guido Ferrari, Zhi Yong Yang, Kelly E. Seaton, Phillip W. Berman, Michael D. Alpert, David T. Evans, Robert J. O'Connell, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Abraham Pinter, Susan Zolla-Pazner, Peter B. Gilbert, Gary J. Nabel, Nelson L. Michael, Jerome H. Kim, David C. Montefiori, Barton F. Haynes, Georgia D. Tomaras Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Science Translational Medicine. Vol.6, No.228 (2014). doi:10.1126/scitranslmed.3007730 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34265

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination

Author(s)

Nicole L. Yates
 Hua Xin Liao
 Youyi Fong
 Allan DeCamp
 Nathan A. Vandergrift
 William T. Williams
 S. Munir Alam
 Guido Ferrari
 Zhi Yong Yang
 Kelly E. Seaton
 Phillip W. Berman
 Michael D. Alpert
 David T. Evans
 Robert J. O'Connell
 Donald Francis
 Faruk Sinangil
 Carter Lee
 Sorachai Nitayaphan
 Supachai Rerks-Ngarm
 Jaranit Kaewkungwal
 Punnee Pitisuttithum
 James Tartaglia
 Abraham Pinter
 Susan Zolla-Pazner
 Peter B. Gilbert
 Gary J. Nabel
 Nelson L. Michael
 Jerome H. Kim
 David C. Montefiori
 Barton F. Haynes
 Georgia D. Tomaras

Other Contributor(s)

Duke University
 Fred Hutchinson Cancer Research Center
 National Institute of Allergy and Infectious Diseases
 University of California, Santa Cruz
 Harvard Medical School
 Armed Forces Research Institute of Medical Sciences, Thailand
 Global Solutions for Infectious Diseases
 Thailand Ministry of Public Health
 Mahidol University
 Sanofi Pasteur
 Rutgers New Jersey Medical School
 NYU School of Medicine
 Walter Reed Army Institute of Research
 Sanofi
 University of Wisconsin Madison

Abstract

HIV-1-specific immunoglobulin G (IgG) subclass antibodies bind to distinct cellular Fc receptors. Antibodies of the same epitope specificity but of a different subclass therefore can have different antibody effector functions. The study of IgG subclass profiles between different vaccine regimens used in clinical trials with divergent efficacy outcomes can provide information on the quality of the vaccine-induced B cell response. We show that HIV-1-specific IgG3 distinguished two HIV-1 vaccine efficacy studies (RV144 and VAX003 clinical trials) and correlated with decreased risk of HIV-1 infection in a blinded follow-up case-control study with the RV144 vaccine. HIV-1-specific IgG3 responses were not long-lived, which was consistent with the waning efficacy of the RV144 vaccine. These data suggest that specific vaccine-induced HIV-1 IgG3 should be tested in future studies of immune correlates in HIV-1 vaccine efficacy trials.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/34265

Collections

Scopus 2011-2015