Publication:
HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

Issued Date

2015-07-15

Resource Type

Article

ISSN

19466242
19466234

DOI

10.1126/scitranslmed.aab4005

Other identifier(s)

2-s2.0-84937131006

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Science Translational Medicine. Vol.7, No.296 (2015)

Suggested Citation

Heather A. Prentice, Georgia D. Tomaras, Daniel E. Geraghty, Richard Apps, Youyi Fong, Philip K. Ehrenberg, Morgane Rolland, Gustavo H. Kijak, Shelly J. Krebs, Wyatt Nelson, Allan DeCamp, Xiaoying Shen, Nicole L. Yates, Susan Zolla-Pazner, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Guido Ferrari, M. Juliana McElrath, David C. Montefiori, Robert T. Bailer, Richard A. Koup, Robert J. O'Connell, Merlin L. Robb, Nelson L. Michael, Peter B. Gilbert, Jerome H. Kim, Rasmi Thomas HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. Science Translational Medicine. Vol.7, No.296 (2015). doi:10.1126/scitranslmed.aab4005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36378

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Title

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

Author(s)

Heather A. Prentice
 Georgia D. Tomaras
 Daniel E. Geraghty
 Richard Apps
 Youyi Fong
 Philip K. Ehrenberg
 Morgane Rolland
 Gustavo H. Kijak
 Shelly J. Krebs
 Wyatt Nelson
 Allan DeCamp
 Xiaoying Shen
 Nicole L. Yates
 Susan Zolla-Pazner
 Sorachai Nitayaphan
 Supachai Rerks-Ngarm
 Jaranit Kaewkungwal
 Punnee Pitisuttithum
 Guido Ferrari
 M. Juliana McElrath
 David C. Montefiori
 Robert T. Bailer
 Richard A. Koup
 Robert J. O'Connell
 Merlin L. Robb
 Nelson L. Michael
 Peter B. Gilbert
 Jerome H. Kim
 Rasmi Thomas

Other Contributor(s)

Walter Reed Army Institute of Research
 HJF
 Duke University School of Medicine
 Fred Hutchinson Cancer Research Center
 Leidos Inc.
 NYU School of Medicine
 Armed Forces Research Institute of Medical Sciences, Thailand
 Thailand Ministry of Public Health
 Mahidol University
 National Institute of Allergy and Infectious Diseases
 Inova Fairfax Medical Campus

Abstract

© 2015, American Association for the Advancement of Science. All rights reserved. In the RV144 vaccine trial, two antibody responses were found to correlate with HIV-1 acquisition. Because human leukocyte antigen (HLA) class II-restricted CD4+T cells are involved in antibody production, we tested whether HLA class II genotypes affected HIV-1-specific antibody levels and HIV-1 acquisition in 760 individuals. Indeed, antibody responses correlated with acquisition only in the presence of single host HLA alleles. Envelope (Env)-specific immunoglobulin A (IgA) antibodies were associated with increased risk of acquisition specifically in individuals with DQB1∗06. IgG antibody responses to Env amino acid positions 120 to 204 were higher and were associated with decreased risk of acquisition and increased vaccine efficacy only in the presence of DPB1∗13. Screening IgG responses to overlapping peptides spanning Env 120-204 and viral sequence analysis of infected individuals defined differences in vaccine response that were associated with the presence of DPB1∗13 and could be responsible for the protection observed. Overall, the underlying genetic findings indicate that HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 trial.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/36378

Collections

Scopus 2011-2015